A Human Fetal Prostate Xenograft Model of Developmental Estrogenization
نویسندگان
چکیده
منابع مشابه
Developmental Exposure to Estrogen Alters Differentiation and Epigenetic Programming in a Human Fetal Prostate Xenograft Model
Prostate cancer is the most frequent non-cutaneous malignancy in men. There is strong evidence in rodents that neonatal estrogen exposure plays a role in the development of this disease. However, there is little information regarding the effects of estrogen in human fetal prostate tissue. This study explored early life estrogen exposure, with and without a secondary estrogen and testosterone tr...
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Most common male reproductive disorders are linked to lower testosterone exposure in fetal life, although the factors responsible for suppressing fetal testosterone remain largely unknown. Protracted use of acetaminophen during pregnancy is associated with increased risk of cryptorchidism in sons, but effects on fetal testosterone production have not been demonstrated. We used a validated xenog...
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ژورنال
عنوان ژورنال: International Journal of Toxicology
سال: 2015
ISSN: 1091-5818,1092-874X
DOI: 10.1177/1091581815569364